Pancytopenia related to Graves' disease.

Ann Saudi Med 28(1) January-February 2008 www.kfshrc.edu.sa/annals 48 Pancytopenia is a serious hematological disorder that, apart from primary marrow failure, may be secondary to several other conditions. These include infection, radiation, drugs (especially cytotoxic drugs), and certain metabolic diseases.1 Among the latter, the association between hyperthyroidism and pancytopenia is reported least commonly.2 The pathog genesis of such an association is not clearly understood, though hypotheses of immunogenic and toxic mechag nisms have been advocated.3 The response of pancytog penia to treatment of hyperthyroidism confirms the cag sual relationship and may preclude any other treatment modalities of pancytopenia.